YAP Induces Human Naive Pluripotency
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- 作者：Han Qin1 ; 2 ; 3 ; 11 ; Miroslav Hejna4 ; 5 ; Yanxia Liu6 ; 7 ; Michelle Percharde1 ; 2 ; 3 ; Mark Wossidlo8 ; 9 ; Laure Blouin1 ; 2 ; 3 ; Jens Durruthy-Durruthy8 ; 9 ; Priscilla Wong1 ; 2 ; 3 ; Zhongxia Qi10 ; Jingwei Yu10 ; Lei S. Qi6 ; 7 ; Vittorio Sebastiano8 ; 9 ; Jun S. Song4 ; 5 ; Miguel Ramalho-Santos1 ; 2 ; 3 ; mrsantos@ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：embryonic stem cells (ESCs) ; induced pluripotent stem cells (iPSCs) ; pluripotent stem cells (PSCs) ; naive pluripotency ; Hippo pathway ; Yes-associated protein (YAP) ; lysophosphatidic acid (LPA)
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：14
- 期：10
- 页码：2301-2312
- 全文大小：4705 K
文摘
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YAP overexpression promotes a naive state in human PSCs
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LPA partially substitutes for YAP in the derivation of transgene-free naive PSCs
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YAP regulates the human naive state by modulating Wnt signaling
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YAP is required for efficient self-renewal of human naive PSCs