Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells
详细信息 查看全文
- 作者：Michael Boice1 ; 2 ; 15 ; Darin Salloum1 ; 15 ; Frederic Mourcin3 ; 15 ; Viraj Sanghvi1 ; Rada Amin3 ; Elisa Oricchio4 ; Man Jiang1 ; Anja Mottok5 ; Nicolas Denis-Lagache6 ; Giovanni Ciriello7 ; 8 ; Wayne Tam9 ; Julie Teruya-Feldstein10 ; Elisa de Stanchina11 ; Wing C. Chan12 ; Sami N. Malek13 ; Daisuke Ennishi5 ; Renier J. Brentjens14 ; Randy D. Gascoyne5 ; Michel Cogné ; 6 ; Karin Tarte3 ; karin.tarte@univ-rennes1.fr" class="auth_mail" title="E-mail the corresponding author ; Hans-Guido Wendel1 ; 16 ; wendelh@mskcc.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：167
- 期：2
- 页码：405-418.e13
- 全文大小：7364 K
文摘
- •
The interaction between HVEM and BTLA is lost in most follicular lymphomas
- •
Loss of HVEM activates B cells and induces a supportive microenvironment
- •
Soluble HVEM (solHVEM) restores the inhibitory BTLA signal and kills lymphoma cells
- •
CAR-T cells that produce solHVEM (“micro-pharmacies”) are active against lymphoma