文摘
Sodium channel isoform Nav1.8 contributions to retinal function were studied using the specific blocker A803467. A803467 had no effect on ERG a- and b-waves, but significantly reduced the oscillatory potentials (OPs). Targeting starburst amacrine cells (SBACs) with the cholinergic neurotoxin AF64A reduced OPs similar to A803467. A803467 affect ON-sustained retinal ganglion cells (RGCs) directly and ON/OFF transient though inhibitory circuits. SBACs, through Nav1.8 modulation, selectively amplify/propagate OPs; Nav1.8 modulates specific aspects of RGC physiology.