Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms

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• 作者：Min Li ; Hongyan Li ; Fang Fang ; Xueyang Deng ; Shiping Ma ; ^{spma@cpu.edu.cn}
• 关键词：Astragaloside IV ; Cerebral ischemia and reperfusion ; Cognitive impairments ; TLR4 signaling pathway ; NLRP3 inflammasome ; Microglial activation
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：114-119
• 全文大小：1442 K
• 卷排序：639

文摘

Astragaloside IV significantly ameliorates cognitive impairments induced by transient cerebral ischemia and reperfusion injury. Astragaloside IV regulates inflammatory responses by inhibiting TLR4 signaling pathway and NLRP3 inflammasome overactivation. Astragaloside IV attenuates cerebral ischemia and reperfusion injury by suppressing the overactivation of microglia.