Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
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- 作者：Igor Koturbasha ; ikoturbash@uams.edu" class="auth_mail" title="E-mail the corresponding author ; Isabelle R. Mioussea ; Vijayalakshmi Sridharanb ; Etienne Nzabarushimanaa ; Charles M. Skinnera ; Stepan B. Melnykc ; Oleksandra Pavlivc ; Martin Hauer-Jensenb ; d ; Gregory A. Nelsone ; Marjan Boermab
- 关键词：Space radiation ; Heart ; One-carbon metabolism pathway ; DNA methylation ; Repetitive elements
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：787
- 期：Complete
- 页码：43-53
- 全文大小：1859 K
文摘
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Radiation-induced dynamic changes in cardiac DNA methylation were detected.
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Early LINE-1 hypomethylation was followed by hypermethylation at a later time-point.
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Radiation affected one-carbon metabolism in the heart tissue.
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Irradiation resulted in accumulation of satellite DNA mRNA transcripts.