Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair
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- 作者：Corina Ohle1 ; 3 ; Rafael Tesorero1 ; 3 ; Gé ; za Schermann1 ; Nikolay Dobrev1 ; Irmgard Sinning1 ; Tamá ; s Fischer1 ; 2 ; 4 ; tamas.fischer@anu.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA repair ; DSB repair ; RNA-DNA hybrids ; R loops ; RNase H ; RPA ; genome stability ; homologous recombination
- 刊名：Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：167
- 期：4
- 页码：1001-1013.e7
- 全文大小：3418 K
文摘
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Deletion or overexpression of RNase H inhibits HR-mediated DSB repair in S. pombe
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RNA polymerase II and RNA-DNA hybrids are enriched around DSB sites
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Stabilization of RNA-DNA hybrids impairs RPA recruitment to ssDNA overhangs
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RNA-DNA hybrids are essential for maintaining repetitive DNA regions around DSBs