An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences

详细信息    查看全文

• 作者：Charles A. Ishak¹ ; ³ ; Aren E. Marshall¹ ; ³ ; Daniel T. Passos¹ ; ³ ; Carlee R. White² ; ³ ; Seung J. Kim¹ ; ³ ; Matthew J. Cecchini¹ ; ⁴ ; Sara Ferwati¹ ; ³ ; William A. MacDonald⁵ ; ⁶ ; Christopher J. Howlett⁴ ; Ian D. Welch⁷ ; Seth M. Rubin⁸ ; Mellissa R.W. Mann⁵ ; ⁶ ; Frederick A. Dick¹ ; ² ; ³ ; ⁹ ; ^fdick@uwo.ca
• 关键词：repetitive DNA ; H3K27me3 ; Polycomb ; retinoblastoma protein ; heterochromatin ; cancer ; epigenetics
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：64
• 期：6
• 页码：1074-1087
• 全文大小：5052 K
• 卷排序：64

文摘

The retinoblastoma protein occupies repetitive sequences in somatic cells RB-EZH2 is required for H3K27me3 deposition at repeats and repression Loss of repeat repression by RB is associated with cancer susceptibility