Repetitive transcranial magnetic stimulation effectively facilitates spatial cognition and synaptic plasticity associated with increasing the levels of BDNF and synaptic proteins in Wistar rats
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- 作者：Yingchun Shanga ; Xin Wangb ; Xueliang Shanga ; Hui Zhanga ; Zhipeng Liub ; Tao Yinb ; bme500@163.com" class="auth_mail" title="E-mail the corresponding author ; Tao Zhanga ; zhangtao@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; brain derived neurotrophic factor ; DEP ; depotentiation ; fEPSP ; field excitatory postsynaptic potentials ; IT ; initial training ; LFS ; low-frequency stimulation ; LTD ; long-term depression ; LTP ; long-term potentiation ; MWM ; Morris water maze ; NMDAR ; N-methyl-d-aspartate receptor ; PPF ; paired-pulse facilitation ; PTP ; post tetanic potentiation ; RET ; reversal exploring test ; RT ; reversal training ; rTMS ; repetitive transcranial magnetic stimulation ; SET ; space exploring test ; STP ; short-time poten
- 刊名：Neurobiology of Learning and Memory
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：134
- 期：part_PB
- 页码：369-378
- 全文大小：1300 K
文摘
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Investigating the mechanism of improving spatial cognition induced by rTMS.
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rTMS facilitates spatial learning and memory abilities in normal rats.
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rTMS significantly enhances synaptic plasticity in the hippocampus.
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rTMS considerably increases the level of BDNF expression in the hippocampus.
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rTMS significantly increases the levels of SYP and NR2B in the hippocampus.