Alterations of functional properties of hippocampal networks following repetitive closed-head injury
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- 作者：Omar C. Loguea ; b ; Nathan P. Cramerb ; Xiufen Xub ; Daniel P. Perlc ; Zygmunt Galdzickib ; zygmunt.galdzicki@usuhs.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPARs ; AMPA receptors ; AP ; action potential ; Ca2 ; + ; ; calcium ; CHI ; closed head injury ; EAE ; experimental autoimmune encephalomyelitis ; fEPSP ; field excitatory postsynaptic potential ; LTP ; long-term potentiation ; mEPSCs ; miniature excitatory postsynaptic currents ; mIPSCs ; miniature inhibitory postsynaptic currents ; mTBI ; mild traumatic brain injury ; PPF ; paired pulse facilitation ; PTSD ; post traumatic stress disorder ; rTAI ; repetitive traumatic axonal injury ; rTBI ; repetitive traumatic
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：277
- 期：Complete
- 页码：227-243
- 全文大小：2718 K
文摘
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Ipsilateral hippocampal CA1 LTP was increased at 1 week following 3 × CHI.
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3 × CHI mice were impaired in hippocampal-dependent behavioral tasks.
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Action potential amplitude was increased with rise & decay times decreased.
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Frequencies of spontaneous excitatory and inhibitory currents were abnormal.
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Results are consistent with 3 × CHI triggering remodeling of hippocampal circuitry.