Early Natural Killer Cell Reconstitution Predicts Overall Survival in T Cell-Replete Allogeneic Hematopoietic Stem Cell Transplantation
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- 作者：Lia Minculescu1 ; lia.minculescu@regionh.dk" class="auth_mail" title="E-mail the corresponding author ; Hanne Vibeke Marquart1 ; Lone Smidstrup Friis2 ; Soeren Lykke Petersen2 ; Ida Schiø ; dt2 ; Lars Peter Ryder1 ; Niels Smedegaard Andersen2 ; Henrik Sengeloev2
- 关键词：HSCT ; T cell replete ; Immune reconstitution ; Natural killer cells ; Infections ; Allogeneic hematopoietic stem cell transplantation
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：22
- 期：12
- 页码：2187-2193
- 全文大小：433 K
文摘
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Early robust NK cell immune recovery predicts outcomes after T cell–replete HSCT.
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NK cell count > 150 cells/µL on day 30 is associated with improved OS and less TRM.
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Low NK cell counts are associated with occurrences of bacterial and viral infections.
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Low NK cell counts are associated with increased risk of CMV reactivation.