Successful T-cell Replete Hematopoietic Stem Cell Boost Without Conditioning for Late Graft Failure

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• 作者：Y. Tsutsumi^a ; ^{yutsutsu@shore.ocn.ne.jp} ; T. Tateno^a ; S. Ito^a ; S. Shiratori^a ; T. Teshima^b
• 刊名：Transplantation Proceedings
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：48
• 期：9
• 页码：3225-3226
• 全文大小：226 K
• 卷排序：48

文摘

Late graft failure is a rare but significant complication after allogeneic stem cell transplantation, which is often complicated by severe infections. We report a case of late graft failure, which was successfully treated with a T-cell replete hematopoietic stem cell boost without conditioning that induced rapid engraftment and relieved the patient of infection. Discontinuation of immunosuppressants and nilotinib administration suppressed the host cells. Achieving full donor chimerism allowed us to administer a peripheral blood stem cell boost without conditioning.