Subversion of Retrograde Trafficking by Translocated Pathogen Effectors

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• 作者：Nicolas Personnic¹ ; Kevin Bä ; rlocher¹ ; Ivo Finsel² ; Hubert Hilbi¹ ; ² ; ^{hilbi@imm.uzh.ch" class="auth_mail" title="E-mail the corresponding author}
• 关键词：bacterial effector protein ; host&ndash ; pathogen interaction ; pathogen vacuole ; phosphoinositide lipid ; retromer ; small GTPase
• 刊名：Trends in Microbiology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：24
• 期：6
• 页码：450-462
• 全文大小：2123 K

文摘

Intracellular bacterial pathogens subvert the endocytic bactericidal pathway to form specific replication-permissive compartments termed pathogen vacuoles or inclusions. To this end, the pathogens employ type III or type IV secretion systems, which translocate dozens, if not hundreds, of different effector proteins into their host cells, where they manipulate vesicle trafficking and signaling pathways in favor of the intruders. While the distinct cocktail of effectors defines the specific processes by which a pathogen vacuole is formed, the different pathogens commonly target certain vesicle trafficking routes, including the endocytic or secretory pathway. Recently, the retrograde transport pathway from endosomal compartments to the trans-Golgi network emerged as an important route affecting pathogen vacuole formation. Here, we review current insight into the host cell's retrograde trafficking pathway and how vacuolar pathogens of the genera Legionella, Coxiella, Salmonella, Chlamydia, and Simkania employ mechanistically distinct strategies to subvert this pathway, thus promoting intracellular survival and replication.