The intracellular dynamics of hepatitis B virus (HBV) replication with reproduced virion “re-cycling‿
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- 作者：Jun Nakabayashi junakabayashi@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatitis B virus ; Chronic hepatitis ; CccDNA ; Recycling
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：7 May 2016
- 年：2016
- 卷：396
- 期：Complete
- 页码：154-162
- 全文大小：840 K
文摘
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The intracellular replication process of HBV is modeled based on the molecular biological findings.
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The effect of recycling of HBV virion for the replication dynamics of HBV is investigated.
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Two replication patterns names “arrested” and “explosive” replication are clarified.
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The threshold for the explosive replication is lowered by recycling of HBV virion.
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Small release rate of virion in HBV replication process may be risk factor for the exacerbation of hepatitis during the long time course of chronic hepatitis.