BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression
详细信息 查看全文
- 作者：Shwu-Yuan Wu1 ; 2 ; Dawn Sijin Nin1 ; A-Young Lee1 ; 3 ; Scott Simanski4 ; Thomas Kodadek4 ; Cheng-Ming Chiang1 ; 2 ; 3 ; cheng-ming.chiang@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：9 August 2016
- 年：2016
- 卷：16
- 期：6
- 页码：1733-1748
- 全文大小：5195 K
文摘
- •
BRD4 phospho-NPS interacts selectively with high-risk HPV E2 protein
- •
Phospho-NPS-targeting compounds block phosphorylation-dependent BRD4 function
- •
Phosphorylated NPS residues are critical for BRD4-mediated HPV origin replication
- •
BRD4 regulates MMP-9 transcription jointly with NF-κB and select AP-1 members