Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans
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- 作者：Esther Pueyoa ; b ; epueyo@unizar.es" class="auth_mail" title="E-mail the corresponding author ; Michele Orinic ; José ; F. Rodrí ; guezd ; Peter Taggartc
- 关键词：Ventricular repolarization oscillations ; beta-Adrenergic stimulation ; Mechanical stretch ; Calcium overload ; Arrhythmogenesis ; Computer modeling.
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：97
- 期：Complete
- 页码：93-105
- 全文大小：1862 K
文摘
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We have modeled low-frequency oscillations in action potential duration (APD).
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Prolonged phasic beta-adrenergic stimulation and stretch lead to APD oscillations.
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The effect of phasic beta-adrenergic stimulation and stretch is synergistic.
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Calcium overload and reduced repolarization reserve enhance APD oscillations.
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Arrhythmogenic events develop following large APD oscillations.