MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53
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- 作者：Magdalena Wienken1 ; 7 ; Antje Dickmanns1 ; 7 ; Alice Nemajerova2 ; Daniela Kramer1 ; Zeynab Najafova3 ; Miriam Weiss1 ; Oleksandra Karpiuk1 ; Moustapha Kassem4 ; Yanping Zhang5 ; Guillermina Lozano6 ; Steven A. Johnsen3 ; Ute M. Moll1 ; 2 ; Xin Zhang1 ; xzhang1@gwdg.de" class="auth_mail" title="E-mail the corresponding author ; Matthias Dobbelstein1 ; mdobbel@gwdg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 January 2016
- 年：2016
- 卷：61
- 期：1
- 页码：68-83
- 全文大小：6225 K
文摘
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MDM2 promotes stemness and enables cancer cell survival independent of p53
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MDM2 binds Polycomb Repressor Complex 2, a key mediator of cell stemness
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MDM2 modifies the repressive ubiquitination and methylation of histones