Repulsive guidance molecule A suppresses angiogenesis
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- 作者：Kana Haradaa ; b ; Yuki Fujitaa ; b ; Toshihide Yamashitaa ; b ; yamashita@molneu.med.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：RGM ; Angiogenesis ; HUAEC ; Neogenin ; Focal adhesion kinase
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：469
- 期：4
- 页码：993-999
- 全文大小：1446 K
文摘
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RGMa inhibits VEGF-induced and VEGF-independent tube formation and migration of HUAEC in vitro.
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RGMa suppresses VEGF-induced angiogenesis in vivo.
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Suppression of angiogenesis in RGMa may offer possible therapeutic application for pro-angiogenic conditions.