Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major
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- 作者：Rodrigo Lombrañ ; a1 ; 3 ; Alba Á ; lvarez1 ; 3 ; José ; Miguel Ferná ; ndez-Justel1 ; Ricardo Almeida1 ; Cé ; sar Poza-Carrió ; n1 ; Fá ; bia Gomes2 ; Arturo Calzada2 ; José ; Marí ; a Requena1 ; Marí ; a Gó ; mez1 ; mgomez@cbm.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA replication origins ; nucleosomes ; replication timing ; transcription ; Leishmania major ; genome-wide mapping
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：9 August 2016
- 年：2016
- 卷：16
- 期：6
- 页码：1774-1786
- 全文大小：3763 K
文摘
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L. major DNA replication origins and nucleosome occupancies are mapped at high resolution
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Those datasets are integrated with mRNA profiling and epigenetic marks
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Nucleosome patterns recapitulate RNA polymerase kinetics
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DNA replication initiates at sites of RNA polymerase pausing and termination