Variations in Initial Renal Transplant Function by Type of Organ Retrieval

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• 作者：A. Gonz谩lez Alfaro ; P. Campos Hern谩ndez ; E. G贸mez G贸mez ; J. Ruiz Garcia ; J.L. Carazo Carazo ; F. M谩rquez L贸pez ; F.J. Anglada Curado ; M. Leva Vallejo ; J.C. Regueiro L贸pez ; P. Aljama ; M.J. Requena Tapia
• 刊名：Transplantation Proceedings
• 出版年：December, 2013
• 年：2013
• 卷：45
• 期：10
• 页码：3603-3605
• 全文大小：194 K

文摘

Background

Numerous factors have been associated with early delay in kidney function and thence the graft survival. However, few data are derived from different types of donation: single or multiorgan. Our goal was to analyze the association of type of retrieval with the early function of the renal graft.

Methods

A retrospective analysis of transplantations performed in the Reina Sofia Hospital from January 2004 to June 2012 from local deceased donors was carried out. We performed a descriptive analysis of the variables and univariate and multivariate analyses with the use of logistic regression to determine the association of type of retrieval (kidney-only [KO], kidney-liver [KL], and multiorgan [MO]) with delayed graft function (DGF) and early graft failure (EGF).

Results

We analyzed 287 kidney transplantations from 182 deceased donors, of which 25 (13.7%) were KO, 80 (43.9%) KL, and 77 (42.3%) MO. DGF was higher in MO retrievals compared with KL and KO (25.8% vs 24% vs 20.5%), though without reaching significance (m>Pm>聽= .81). EGF at 3 months was 17.6% in KO compared with 10.5% in KL and 5.3% in MO聽(m>Pm>聽= .2). Regarding DGF, in the multivariate analysis, donor age (m>Pm>聽= .049) and donor sex (m>Pm>聽= .029) appeared to be related to DGF. There were no differences by type of retrieval. Multivariate logistic regression analysis established a significant relationship between KO retrieval and EGF at 3 months (m>Pm>聽= .005) compared with MO.

Conclusions

Early graft function at 3 months decreases when the allograft is from KO retrievals compared with MO, probably related to the more unfavorable characteristics of聽these donors and their corresponding recipients.