Endoplasmic reticulum stress and dysregulation of calcium homeostasis mediate Cu-induced alteration in hepatic lipid metabolism of javelin goby Synechogobius hasta
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- 作者：Yu-Feng Songa ; Chao Huanga ; Xi Shia ; Ya-Xiong Pana ; Xu Liuc ; Zhi Luoa ; b ; 1 ; luozhi99@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; luozhi99@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACC ; acetyl-CoA carboxylase ; ATF6 ; activating transcription factor 6 ; 2-APB ; 2-aminoethyldiphenyl borate ; CRT ; calreticulin ; DMSO ; dimethyl sulfoxide ; eIF2α ; eukaryotic translation initiation factor 2 alpha ; FAS ; fatty acid synthase ; FBS ; fetal bovine serum ; GRP78/BiP ; 78-kDa glucose-regulated protein ; IP3 ; inositol 1 ; 4 ; 5-trisphosphate ; IRE1 ; inositol-requiring enzyme 1 ; LXR ; liver X receptor ; MS-222 ; 3-aminobenzoic acid ethyl ester methanesulfonate ; M199 ; medium 199 ; PBS ; phosphate buffered s
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：175
- 期：Complete
- 页码：20-29
- 全文大小：1704 K
文摘
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The full-length cDNA sequences of five ERS-related genes were firstly characterized from S. hasta.
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10">Cu exposure evoked ER stress in liver of S. hasta.
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15">Ca2+ release from ER was involved in the Cu-induced ER stress change.
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Cu-induced alteration in lipid metabolism was suppressed through the attenuation of ER stress.
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Cu exposure evoked ER stress and SREBP-1c activation in hepatocytes of S. hasta, resulting in dysregulation of hepatic lipid metabolism.