Inhibition of ABC transport proteins by oil sands process affected water
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- 作者：Hattan A. Alharbia ; David M.V. Saundersa ; Ahmed Al-Mousab ; Jane Alcorna ; b ; Alberto S. Pereirac ; Jonathan W. Martinc ; John P. Giesya ; d ; e ; f ; g ; h ; jgiesy@aol.com" class="auth_mail" title="E-mail the corresponding author ; Steve B. Wisemana ; steve.wiseman@usask.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Naphthenic acid ; Orbitrap mass spectrometry ; Efflux transporters ; Multidrug resistance-associated protein ; Chemosensitization
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：170
- 期：Complete
- 页码：81-88
- 全文大小：1129 K
文摘
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Effects of OSPW on activities of MRP transporters was investigated.
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Chemicals in fresh, but not aged OSPW inhibited activity of MRPs.
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O+, SO+, and NO+ species, but not naphthenic acids (O2−) inhibit MRPs.