Pharmacokinetics and tissue distribution of 5,7-dimethoxyflavone in mice following single dose oral administration
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- 作者：Di Beia ; Guohua Anb ; guohua-an@uiowa.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：5 ; 7-DMF ; 5 ; 7-Dimethoxyflavone ; PK ; pharmacokinetic ; LC&ndash ; MS/MS ; Liquid chromatography&ndash ; tandem mass spectrometry ; CYP ; Cytochrome P450 ; P-gp ; P-glycoprotein ; MRP ; multidrug resistance associated-proteins ; BCRP ; Breast Cancer Resistance Protein ; MDR ; multidrug resistance ; LLOQ ; lower limit of quantification ; PBS ; phosphate-buffered saline ; I.S ; internal standard ; QC ; quality control ; HPL ; Chigh performance liquid chromatogram ; NCA ; non-compartmental analysis ; XIC ; extracted ion chromatogr
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：119
- 期：Complete
- 页码：65-70
- 全文大小：879 K
文摘
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The PK and tissue distribution of 5,7-DMF was evaluated for the first time in mice
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Peak 5,7-DMF concentrations in mouse plasma and tissues were reached within 30 min.
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5,7-DMF oral dose led to extensive tissue distribution.
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5,7-DMF was abundant in gut > liver > kidney > brain > spleen > heart > lung > adipose > muscle.
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The partition coefficient (Kp) of these tissues were 0.65 to 12.9.