A dermatologist guide to immunogenicity

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• 作者：Collin M. Blattner ; DO^a ; Soham P. Chaudhari ; DO^b ; John Young III ; MD^c ; Jenny E. Murase ; MD^d ; ^e ; ^{jemurase@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：antidrug antibodies ; autoantibodies ; biologic fatigue ; HACA antibodies ; resistance to biologics
• 刊名：International Journal of Women's Dermatology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：2
• 期：3
• 页码：77-84
• 全文大小：462 K

文摘

Dermatologists should be aware that autoantibody formation may occur after the initiation of biologic therapy. This phenomenon has been referred to as immunogenicity and biologic fatigue. Because of this, patients may experience loss of clinical efficacy to a particular drug. To combat this phenomenon, low-dose immunomodulators may be used in hopes of preventing autoantibodies. We review the current literature and provide a basic treatment algorithm for patients with moderate to severe psoriasis.