MiR-106a: Promising biomarker for cancer

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• 作者：Yao-Jie Pan^b ; ^&dagger ; ; Ying Zhuang^a ; ^&dagger ; ; Jun-Nian Zheng^b ; ^c ; ^d ; ^{jnzheng@xzmc.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Dong-Sheng Pei^a ; ^b ; ^c ; ^{dspei@xzmc.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：MiRNAs ; micro RNAs ; FASTK ; Fas-activated serine/threonine kinase ; MAPK ; mitogen-activated protein kinase ; NSCLC ; non-small cell lung cancer ; P-gp ; P-glyco-protein ; MDR ; multidrug resistance ; ABCA1 ; adenosine triphosphatase-binding cassette A1 ; TIMP2 ; tissue inhibitor of metalloproteinases-2 ; MMPs ; matrix metalloproteinases ; ECM ; extracellular matrix ; BM ; basement membrane ; TLRs ; Toll-like receptors ; LPS ; lipopolysaccharide ; DIM ; 3 ; 3&prime ; -Diindolylmethane ; GalN/LPS ; d-galactosamine and lipopoly
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：26
• 期：22
• 页码：5373-5377
• 全文大小：481 K

文摘

MicroRNAs (miRNAs), which are characterized by highly conserved and small non-coding RNAs, have been a hot spot regarding biological processes such as cellular proliferation, apoptosis and metabolism as well as cellular differentiation, signal transduction and carcinogenesis.

MiRNA-106a (miR-106a), a member of the miR-17 family, has been validated to be aberrantly regulated in the diversity of tumors. The purpose of this review is supposed to deliver an intricate overview of miR-106a, including its role in cell proliferation, apoptosis, cell cycle, invasion and metastasis, involvement in drug resistance as well as its interactions with the target proteins and signaling pathways involved.