Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity

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• 作者：Alessandra Bisi^a ; ^{alessandra.bisi@unibo.it} ; Concettina Cappadone^b ; ^{concettina.cappadone@unibo.it} ; Angela Rampa^a ; Giovanna Farruggia^b ; ^c ; Azzurra Sargenti^b ; Federica Belluti^a ; Rita M.C. Di Martino^a ; ¹ ; Emil Malucelli^b ; Alessia Meluzzi^b ; Stefano Iotti^b ; ^c ; Silvia Gobbi^a
• 关键词：P-glycoprotein ; Anticancer ; Coumarin ; MDR modulators ; Chemosensitizers
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：577-585
• 全文大小：1277 K
• 卷排序：127

文摘

A small series of coumarin derivatives were designed and synthesized. Antitumor profile and MDR reverting ability of the new compounds were evaluated. Some derivatives act as cytotoxic compounds and counteract MDR phenomenon. Compound 1e emerged as the most interesting, showing a multipotent biological profile. Molecular hybridization appears an attractive strategy for multifactorial diseases.