Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin

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• 作者：Yuedi Ding ^{dingyuedi@jsinm.org} ; Ying Peng ; Lili Deng ; Jun Fan ; Biao Huang ; ^{huangbiao@jsinm.org}
• 关键词：Atorvastatin ; γ-tocotrienol ; Mevalonate pathway ; Multidrug resistance
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：67-77
• 全文大小：2743 K
• 卷排序：167

文摘

γ-Tocotrienol effectively reversed the multidrug resistance of MCF-7/Adr. Mevalonate pathway partly involved in the reversal ability of γ-tocotrienol. Inhibition of P-gp expression is another mechanism of multidrug reversal.