Competing endogenous RNA networks of CYP4Z1 and pseudogene CYP4Z2P confer tamoxifen resistance in breast cancer
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- 作者：Lufeng Zhenga ; b ; 1 ; Xiaoman Lid ; 1 ; Xia Menga ; b ; Jinjiang Choua ; b ; Jinhang Hua ; b ; Feng Zhanga ; b ; Zhiting Zhanga ; b ; Yingying Xinga ; b ; Yu Liuc ; Tao Xia ; b ; xitao18@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ceRNA ; Breast cancer ; Tamoxifen resistance ; CDK3 ; Pseudogene ; 3&prime ; UTR
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：427
- 期：Complete
- 页码：133-142
- 全文大小：3354 K
文摘
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A new critical role of ceRNAs in ER + breast cancer is proposed.
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We examine the relationship of CYP4Z2P, CYP4Z1 and CDK3 in breast cancer.
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The roles of CYP4Z2P and CYP4Z1 in TAM resistance were further studied.
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The novel mechanism provides new insights for TAM resistance.