Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes
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- 作者：Junjian Wanga ; Zhijian Duana ; Zoann Nugentb ; June X. Zoua ; Alexander D. Borowskyc ; Yanhong Zhangc ; Clifford G. Teppera ; Jian Jian Lid ; Oliver Fiehne ; Jianzhen Xuf ; Hsing-Jien Kunga ; g ; Leigh C. Murphyb ; Hong-Wu Chena ; g ; hwzchen@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Histone methyltransferase ; NSD2 ; Tamoxifen resistance ; Pentose phosphate pathway ; Metabolism
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：10 August 2016
- 年：2016
- 卷：378
- 期：2
- 页码：69-79
- 全文大小：3098 K
文摘
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NSD2 protein overexpression is significantly associated with tamoxifen resistance and poor survival in ER+ tumors/patients.
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NSD2 drives tamoxifen resistance in cell and xenograft tumor models.
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NSD2 directly stimulates the expression of three key PPP-promoting enzymes, namely, HK2, G6PD and TIGAR.