Renewal of an old European Pharmacopoeia method for Terazosin using modeling with mass spectrometric peak tracking

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• 作者：Ró ; bert Kormá ; ny^a ; ^{kormany.robert@egis.hu} ; Imre Molná ; r^b ; Jenő Fekete^a
• 关键词：Terazosin ; Design of experiments ; Quality by design ; DryLab ; UHPLC ; QDa detector
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：135
• 期：Complete
• 页码：8-15
• 全文大小：1969 K
• 卷排序：135

文摘

We developed UHPLC method for Terazosin related substances by DryLab software using mass spectrometry supported peak tracking. The predicted retention times and resolution of critical peak pair were in good agreement with the experimental ones. We reduce the analysis time of Terazosin Ph. Eur. related substances HPLC method from 90 min (2 × 45 min) to below 5 min.