Role of Extracorporeal Membrane Oxygenation in Aluminum Phosphide Poisoning-Induced Reversible Myocardial Dysfunction: A Novel Therapeutic Modality

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• 作者：Bishav Mohan ; MD ; DM^&lowast ; ; Vivek Gupta ; DA ; DNB^&dagger ; ; Sarju Ralhan ; MS ; MCH^&Dagger ; ; Dinesh Gupta ; MD^&dagger ; ; Sandeep Puri ; MD^§ ; ; Gurpreet Singh Wander ; MD ; DM^&lowast ; ; Bhupinder Singh ; MD ; DM^&lowast ; ;
• 关键词：aluminum phosphide ; myocardial depression ; extracorporeal membrane oxygenation ; metabolic acidosis ; resistant shock
• 刊名：Journal of Emergency Medicine
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：49
• 期：5
• 页码：651-656
• 全文大小：321 K

文摘

Aluminum phosphide (AlP) poisoning carries a high rate of mortality despite intensive care management, primarily because of refractory myocardial depression, resistant hypotension, and severe metabolic acidosis as well as acute respiratory distress syndrome. Extracorporeal membrane oxygenation (ECMO) is a modified “heart–lung” machine to provide temporary cardiorespiratory support. We studied the novel use of ECMO in the management of a subset of patients with AlP poisoning.

Case Report

In this case series, seven patients with AlP poisoning suffering from severe metabolic acidosis and refractory cardiogenic shock with a reduced left ventricular ejection fraction (<35%) received ECMO treatment. The acidosis and hemodynamic status improved within 6–12 h and 12–24 h, respectively, in five patients. Two patients did not survive because of a long delay in presentation after ingestion. The majority of the patients developed dysrhythmias, ECMO cannulation site bleeding, and thrombocytopenia. Two patients required surgical exploration of the femoral artery. At 9 months of follow-up, all five surviving patients were doing well, with the near normalization of ventricular function.

Why Should an Emergency Physician be Aware of This?

We have found that timely intervention with ECMO in patients with AlP poisoning–induced severe metabolic acidosis and refractory cardiogenic shock may lead to a significant improvement in overall survival. Therefore, ECMO might be considered as a bridge therapy for patients with intractable cardiorespiratory failure caused by AlP poisoning who are not responding to conventional treatment. ECMO, however, also is associated with significant complication rates, which must be incorporated into the risk-benefit analysis while considering treatment options.