Discovery of unique and ENM‿specific pathophysiologic pathways: Comparison of the translocation of inhaled iridium nanoparticles from nasal epithelium versus alveolar epithelium towards the brain of rats
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- 作者：Wolfgang G. Kreyling1 ; kreyling@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Iridium nanoparticle ; Nose-only and intratracheal inhalation ; Brain accumulation ; Neuronal pathway from upper respiratory tract ; Systemic pathway from lower respiratory tract ; Quantitative biokinetics
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：299
- 期：Complete
- 页码：41-46
- 全文大小：343 K
文摘
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Nanoparticle (NP) translocation from nose versus lungs to brain is differentiated.
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Differential exposure of 20 nm radio-NP:nose-only versus intratracheal inhalation
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The nose-brain path precedes via nerves, the lungs-brain path via circulation.
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NP uptake in the rat brain is nine-fold higher from nose than from lungs.
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Relative to deposited NP in both regions it is 45-fold higher than from the nose.