- 作者：Jennifer E. Schuster ; MD ; MSCI ; jeschuster@cmh.edu" class="auth_mail" title="E-mail the corresponding author ; jnewland1@cmh.edu" class="auth_mail" title="E-mail the corresponding author ; Jason G. Newland ; MD ; MEd
- 关键词：acute respiratory tract infection ; enterovirus ; EV-D68 ; outbreak ; pediatric
- 刊名：Clinical Therapeutics
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：37
- 期：11
- 页码：2411-2418
- 全文大小：303 K
Methods
We reviewed the role of Children’s Mercy Hospital as one of the first hospitals to recognize the 2014 EV-D68 outbreak in the United States. The steps of outbreak management were applied to real-life examples as the outbreak unfolded at our hospital.
Findings
Management of the 2014 EV-D68 outbreak was a multifaceted effort requiring close coordination with hospitals, local and state health departments, and the Centers for Disease Control and Prevention. The importance of clear and frequent communication is highlighted both intra- and interinstitutionally. Increased respiratory disease−related pediatric admissions at hospitals nationally were attributed to EV-D68. Outcomes for these children, including the association of EV-D68 with acute flaccid myelitis, remain under investigation.
Implications
Following the steps of outbreak management is critical to providing optimal patient care and ensuring the health of the public. During the 2014 EV-D68 outbreak, close adherence to outbreak principles led to swift recognition of illness, rapid diagnostic measures, institution of appropriate therapies, and dissemination of information to health care providers and the public. Equally important was the subsequent identification of an increase in acute flaccid myelitis cases against the backdrop of an increase in EV-D68 detections nationally. Future prospective studies are needed to determine the true burden of EV-D68 disease, potential vaccines and therapeutics, and outcomes of children with EV-D68 infection.