DNA mismatch repair and the DNA damage response

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• 作者：Zhongdao Li¹ ; Alexander H. Pearlman¹ ; Peggy Hsieh ; ^{peggyh@niddk.nih.gov" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Mismatch repair ; Lynch syndrome ; DNA damage response ; Mutagenesis ; Colorectal cancer
• 刊名：DNA Repair
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：38
• 期：Complete
• 页码：94-101
• 全文大小：144 K

文摘

This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response (DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on findings from mammalian cells, much has been learned from studies in other organisms including bacteria and yeast 0005 and 0010. MMR promotes a DDR mediated by a key signaling kinase, ATM and Rad3-related (ATR), in response to various types of DNA damage including some encountered in widely used chemotherapy regimes. An introduction to the DDR mediated by ATR reveals its immense complexity and highlights the many biological and mechanistic questions that remain. Recent findings and future directions are highlighted.