Circadian rhythm of the Leydig cells endocrine function is attenuated during aging
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- 作者：Aleksandar Z. Baburski ; Srdjan J. Sokanovic ; Maja M. Bjelic ; Sava M. Radovic ; Silvana A. Andric ; Tatjana S. Kostic ; tatjana.kostic@dbe.uns.ac.rs" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bmal1 ; brain-muscle Arnt-like protein 1 ; BSA ; bovine serum albumin ; cAMP ; cyclic adenosine monophosphate ; Ck1 ; gene for casein kinase 1 ; Clock/CLOCK ; gene/protein for circadian locomotor output cycles kaput ; CRE ; cAMP-responsive element ; Creb/CREB ; gene/protein for cAMP response element-binding protein ; Cry/CRY ; gene/protein for cryptochrome ; Cyp11a/CYP11a ; gene/protein for cytochrome P450 side chain cleavage enzyme ; Cyp17a/CYP17a ; gene/protein for 17α-hydroxylase/C17-20 lyase ; DBP ; D site of al
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：5-13
- 全文大小：1278 K
文摘
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Aging lowered circadian serum testosterone variations.
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Aging decline circadian expression of key steroidogenic and clock genes.
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Cholesterol metabolism and uptake are dampened in Leydig cells from aged rats.
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During aging the changes in steroidogenesis precede changes in clock network.
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Reduced circadian expression of Nampt/Sirt1 pointed decreased cellular metabolism.