Synthesis and characterization of non-toxic and thermo-sensitive poly(N-isopropylacrylamide)-grafted cashew gum nanoparticles as a potential epirubicin delivery matrix
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- 作者：Clara M.W.S. Abreua ; Haroldo C.B. Paulab ; Vitor Seabrac ; Judith P.A. Feitosaa ; Bruno Sarmentoc ; d ; e ; Regina C.M. de Paulaa ; rpaula@dqoi.ufc.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：N-isopropylacrylamide ; Nanoparticles ; Thermo-sensitive ; Cytotoxicity ; Epirubicin
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：10 December 2016
- 年：2016
- 卷：154
- 期：Complete
- 页码：77-85
- 全文大小：969 K
文摘
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Cashew gum grafted N-isopropylacrylamide was successfully synthesized.
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The graft copolymer demonstrated thermal responsiveness.
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The nanoparticles showed no cytotoxic activity against the Caco-2 and HT29-MTX.
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Copolymer shows good epirubicin association efficiency.