Effects of the chronic restraint stress induced depression on reward-related learning in rats

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• 作者：Pan Xu^a ; Kezhu Wang^a ; Cong Lu^a ; Liming Dong^a ; Yixi Chen^c ; Qiong Wang^c ; Zhe Shi^a ; Yanyan Yang^b ; Shanguang Chen^b ; Xinmin Liu^a ; ^{liuxinmin@hotmail.com}
• 关键词：Chronic restraint stress ; Depression ; Instrumental learning ; Reward ; Rat
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：321
• 期：Complete
• 页码：185-192
• 全文大小：1773 K
• 卷排序：321

文摘

It was the first time to evaluate the effects of restraint stress on the performance of reward-motivated instrumental learning tasks of rats. Chronic restraint stress influenced the Pavlovian conditioning, acquisition and maintenance of instrumental conditioning task of rats. The learning ability of rats faced in higher fixed ratio schedule of instrumental learning task was impaired by chronic restraint stress. Chronic stress induced bad performances in instrumental learning tasks might be related to the reduced motivation and cognitive function.