Individual and interactive sex-specific effects of acute restraint and systemic IFN-γ treatment on neurochemistry

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• 作者：Darcy Litteljohn ; ^{dlitteljohn@gmail.com} ; Chris Rudyk ; Sara Razmjou ; Zach Dwyer ; Shuaib Syed ; Shawn Hayley ; ^{shawn.hayley@carleton.ca}
• 关键词：Depression ; Inflammation ; Cytokine ; Sex difference ; Stress response ; HPA axis
• 刊名：Neurochemistry International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：95-104
• 全文大小：1351 K
• 卷排序：102

文摘

Acute systemic IFN-γ sex-dependently stimulates monoaminergic activity within a number of stressor-sensitive limbic brain regions. IFN-γ interacts synergistically with acute restraint stress to increase plasma corticosterone levels. These effects are largely reminiscent of the neurochemical changes induced by other depression-linked inflammatory cytokines in comparable acute exposure experimental paradigms. The pattern of HPA and brain monoamine variations induced by IFN-γ is consistent with a role in the regulation of emotional and cognitive processes.