Use of grapevine cell cultures for the production of phytostilbenes of cosmetic interest

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• 作者：Philippe Jeandet ; ^{philippe.jeandet@univ-reims.fr" class="auth_mail" title="E-mail the corresponding author} ; Christophe Clé ; ment ^{christophe.clement@univ-reims.fr" class="auth_mail" title="E-mail the corresponding author} ; Lé ; o-Paul Tisserant ^{leo-paul.tisserant@univ-reims.fr" class="auth_mail" title="E-mail the corresponding author} ; Jé ; rô ; me Crouzet ^{jerome.crouzet@univ-reims.fr" class="auth_mail" title="E-mail the corresponding author} ; É ; ric Courot ^{eric.courot@univ-reims.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Phytostilbenes ; Resveratrol ; Bioproduction ; Cell suspensions ; Cosmetics ; Grapevine
• 刊名：Comptes Rendus Chimie
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：19
• 期：9
• 页码：1062-1070
• 全文大小：478 K

文摘

Plant cell cultures constitute pesticide-free sources for obtaining plant secondary metabolites or plant extracts. Additionally, they do not contain any fungal contaminants, mycotoxins or heavy metals providing to the consumer potential health benefits and justifying the development of this technology at an industrial scale. Significant production levels of these secondary metabolites can be obtained through the use of elicitors, which activate plant defense mechanisms. Resveratrol, a well-known grapevine polyphenolic compound which possesses potent antioxidant and antiaging activities as well as a protective action on skin, is a good example of such plant secondary metabolites. Resveratrol and its oligomeric derivatives are used by several companies of cosmetic products but their extraction from vine stems and similar vegetal sources remains difficult. Therefore grapevine cell suspensions could represent interesting systems for the large-scale bioproduction of those compounds. Here we present an update of the methods used for the production of phytostilbenes by using grapevine cell cultures and the results obtained.