Fmr1 KO mice show abnormal spine density, length and morphology in the hippocampus.
Fmr1 KO mice present alterations in neurogenesis in the hippocampal dentate gyrus.
Exaggerated mGluR-dependent LTD occurs in the hippocampal CA1 of Fmr1 KO mice.
Hypofunction of NMDA receptors occurs in the hippocampal DG of Fmr1 KO mice.
Deficits in hippocampal plasticity may underlie behavioural abnormalities in FXS.