A novel nanoparticles impregnated ocular insert for enhanced bioavailability to posterior segment of eye: In vitro, in vivo and stability studies
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- 作者：Lalaji V. Rathod ; Rakhee Kapadia ; Krutika K. Sawant ; dr_krutikasawant@rediffmail.com
- 关键词：ACZ ; Acetazolamide ; IOP ; intra ocular pressure ; NPs ; Nanoparticles ; PVA ; polyvinyl alcohol ; EE ; Entrapment efficiency ; DR ; Drug release ; PDI ; poly dispersive index
- 刊名：Materials Science and Engineering: C
- 出版年：2017
- 出版时间：1 February 2017
- 年：2017
- 卷：71
- 期：Complete
- 页码：529-540
- 全文大小：1305 K
- 卷排序：71
文摘
The present investigation reports a novel nanoparticle impregnated ocular inserts. It demonstrates a novel method to enhance retention time of drug in eye. It explores use of nanoparticle impregnated ocular inserts for treatment of eye diseases. This investigation reports a novel formulation for ophthalmic drug delivery.