In vivo drug delivery of gemcitabine with PEGylated single-walled carbon nanotubes
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- 作者：Ali Razzazana ; Fatemeh Atyabib ; c ; atyabifa@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Bahram Kazemid ; Rassoul Dinarvandb ; c
- 关键词：GEM ; gemcitabine ; SWCNTs ; single-walled carbon nanotubes ; MWCNTs ; multi-walled carbon nanotubes ; PEG ; polyethylene glycol ; RNR ; ribonucleotide reductase ; EPR ; enhanced Permeability and Retention effect ; RES ; reticuloendothelial systems ; TEA ; triethylamine ; SOCl2 ; thionyl chloride ; EDA ; ethylenediamine ; DMF ; dimethylformamide ; DMAP ; dimethylaminopyridine ; DBDC ; di-tert-butyl dicarbonate ; SiO2 ; silicon dioxide ; MgSO4 ; magnesium sulfate ; DMSO ; dimethyl sulfoxide ; FITC ; fluorescein isothiocyanate ; E
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：614-625
- 全文大小：2456 K
文摘
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We prepared gemcitabine conjugated to SWCNT and PEGylated SWCNT.
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High drug loading, good release time and improved stability of GEM were achieved.
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The intracellular localization of hydrophilic anticancer drug (GEM) was enhanced.
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The conjugates showed notable cytotoxicity against the A549 and MIA PaCa-2 cells.
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The SWCNT-PEG-GEM conjugates could efficiently inhibit tumor growth in nude mice.