N-methyl-N-nitrosourea-induced neuronal cell death in a large animal model of retinal degeneration in vitro
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- 作者：Linné ; a Taylor ; linnea.taylor@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Karin Arné ; r ; Fredrik Ghosh
- 关键词：N-methyl-N-nitrosourea ; Retinal explant culture ; Porcine retina ; Neuronal degeneration ; Gliosis ; Retinal transplantation
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：55-64
- 全文大小：3385 K
文摘
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We show that N-methyl-N-nitrosourea (MNU) causes degeneration of retinal neurons and glia in the adult porcine retina.
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Explants treated with low concentrations of MNU display attenuation of gliosis, despite decreased neuronal survival.
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Our results have impact on our understanding of gliosis related neuronal degenerative cell death.