文摘
Retinal neovascularization model was established by treating HRECs with high glucose and insulin (HGI). Sirt3 inhibited HGI-induced expression of migration-related genes, including MMP-2 and MMP-9. Sirt3 inhibited HGI-induced expression of angiogenesis-related genes, including VEGF, HIF-1α, and IGF-1. Sirt3 promoted the expression of an autophagy gene, LC3, under HGI induction. Sirt3 may inhibit HGI-induced retinal neovascularization by regulating cell migration and autophagy.