Tumor suppressor gene, retinoic acid receptor β2 (RARβ2), was suppressed in CTCL.
The combination of retinoid with histone acetylation agent restored RARβ2 in CTCL.
The combination treatment inhibited cell growth by apoptosis in vitro.
The combination treatment suppressed tumor growth and prolonged survival in vivo.
This is first report of histone acetylation as primary in restoration of RARβ2.