Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy
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- 作者：Victoria Klepsch ; Natascha Hermann-Kleiter ; Gottfried Baier ; gottfried.baier@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP-1 ; activation protein 1 ; CTLA-4 ; cytotoxic T lymphocyte-associated protein-4 ; GM-CSF ; granulocyte-macrophage colony-stimulating factor ; IL-2 ; interleukin 2 ; IFNƴ ; interferon ƴ ; NFAT ; nuclear factor of activated T cells ; NR2F6 ; nuclear receptor subfamily 2 ; group F ; member 6 - alias ; Ear2/COUP-TFIII ; PD-1/PD-L1 ; programmed cell death-1 and its ligand-1 ; PKC ; protein kinase C ; RORC ; retinoid-related orphan receptor ƴ &ndash ; alias ; RORƴt or NR1F3 ; TCR ; T cell receptor ; TIL ; tumor infiltrating l
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：178
- 期：Complete
- 页码：31-36
- 全文大小：860 K
文摘
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Genetic ablation of Nr2f6 induces immune-mediated cancer rejection.
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Nr2f6−/− mice display an immune contexture favoring cancer immunity.
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NR2F6 represses transcription of key cytokines in CD4+ and CD8+ effector T cells.
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NR2F6 negatively controls host-protective tumor immunity.