Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent
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- 作者：Sayantani Sinha ; Sinhas@email.chop.edu" class="auth_mail" title="E-mail the corresponding author ; Kenta Uchibe ; Yu Usami ; Maurizio Pacifici ; Masahiro Iwamoto ; IwamotoM@email.chop.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HO ; heterotopic ossification ; FOP ; Fibrodysplasia Ossificans Progressiva ; RAR ; retinoic acid receptor ; BMP ; bone morphogenetic protein ; GRE ; glucocorticoid response element ; RARE ; retinoic acid response element ; ACVR1 ; activin receptor 1 ; ALK2 ; activin receptor-like kinase-2 ; NSAIDs ; non-steroidal anti-inflammatory drugs
- 刊名：Bone
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：59-68
- 全文大小：1529 K
文摘
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Heterotopic ossification (HO) is a pathology triggered by injury or mutations for which there is no definitive treatment.
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Corticosteroids and retinoid agonists have been shown to dampen HO, but not fully.
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Here we studied how these diverse drugs act on this pathology.