Irradiating the Subventricular Zone in Glioblastoma Patients: Is there a Case for a Clinical Trial?

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• 作者：B. Nourallah^&lowast ; ; ^&dagger ; ; R. Digpal^&dagger ; ; R. Jena^&Dagger ; ; C. Watts^&lowast ; ; ^§ ; ; ^{cw209@cam.ac.uk}
• 关键词：Cancer stem cells ; glioblastoma ; neural stem cells ; radiotherapy ; subventricular zone
• 刊名：Clinical Oncology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：29
• 期：1
• 页码：26-33
• 全文大小：576 K
• 卷排序：29

文摘

Glioblastoma is the most common and aggressive adult brain tumour. Over the last 10 years it has emerged that the subventricular zone (SVZ), the largest adult neural stem cell niche, has an important role in the disease. Converging evidence has implicated transformation of adult neural stems in gliomagenesis and the permissive stem cell niche in disease recurrence. Concurrently, clinical studies have suggested that SVZ involvement is a negative prognostic marker. It would follow that irradiating the SVZ may improve outcomes in glioblastoma by directly targeting this putative sanctuary site. To investigate this potential strategy, 11 retrospective studies and 1 prospective study examined the relationship between dose to the SVZ and survival outcomes in glioblastoma patients. This review summarises the theoretical underpinning of this strategy, provides a critical evaluation of the existing evidence and discusses the rationale for a clinical trial.