Epstein-Barr virus and multiple sclerosis. From evidence to therapeutic strategies
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- 作者：Santiago Ferná ; ndez-Mené ; ndeza ; sfmenendez@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Marta Ferná ; ndez-Morá ; nb ; Ivá ; n Ferná ; ndez-Vegac ; Angel Pé ; rez-Á ; lvareza ; Javier Villafani-Echazú ; a
- 关键词：BBB ; blood&ndash ; brain barrier ; CIS ; clinically isolated syndrome ; CNS ; central nervous system ; CSF ; Cerebrospinal Fluid ; EBV ; Epstein&ndash ; Barr virus ; HERVs ; Human endogenous retroviruses ; HERV-W ; W family of human endogenous retroviruses ; MRI ; magnetic resonance imaging ; MS ; multiple sclerosis ; MSRV ; multiple sclerosis associated retrovirus ; NK ; natural killer ; OCB ; oligoclonal bands ; OR ; odds ratio ; RRMS ; Relapsing remitting multiple sclerosis
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：361
- 期：Complete
- 页码：213-219
- 全文大小：672 K
文摘
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We made a review of the bibliography for EBV and MS.
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The association between MS and EBV infection may be a causal relationship.
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The role of EBV infected B-cells in the pathogenesis of MS seems to be essential.
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EBV infected B-cells might have a direct or indirect role in the pathogenic mechanisms.
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Anti-B cell treatments appear to be a good strategy for anti-EBV therapy.