• 作者：Raphaë ; l Faucard^a ; ¹ ; Alexandra Madeira^a ; ¹ ; Nadè ; ge Gehin^a ; Franç ; ois-Jé ; rô ; me Authier^b ; ^c ; Petrica-Adrian Panaite^d ; Catherine Lesage^f ; Ingrid Burgelin^e ; Mé ; lanie Bertel^a ; Corinne Bernard^e ; Franç ; ois Curtin^e ; Aloï ; s B. Lang^e ; Andreas J. Steck^d ; Hervé ; Perron^a ; ^e ; ^{hp@geneuro.com" class="auth_mail" title="E-mail the corresponding author} ; Thierry Kuntzer^d ; ² ; Alain Cré ; ange^f ; ²
• 关键词：CIDP ; Peripheral neuropathies ; Schwann cell ; Endogenous retrovirus ; HERV ; HERV-W ; MSRV ; GNbAC1
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：6
• 期：Complete
• 页码：190-198
• 全文大小：1134 K

•

A protein from endogenous retroviruses (8% of human genome) is found in chronic inflammatory demyelinating polyradiculoneuropathies (CIDP).

•

Identified in multiple sclerosis, MSRV-Env induces inflammation and autoimmunity.

•

It is now shown in peripheral nerve lesions, serum and blood cells of CIDP patients.

•

In Schwann cells, it induces pro-inflammatory factors; the same is detected in serum.

•

Antibody neutralization of MSRV-Env effects raises therapeutic perspectives in CIDP.

Since the 1980's, a new horizon in the search for pathogenic players in complex human disease arose from studies in which human endogenous retrovirus families (HERV) were identified. HERVs represent 8% of the human genome and may express pathogenic proteins as shown here in a chronic inflammatory demyelinating polyradiculoneuropathies (CIDPs). The present study shows that MSRV-Env, an HERV protein, is detected in CIDP lesions and blood. It triggers inflammation in immune and nervous cells. A specific antibody revealed efficient in experimental conditions. This offers new therapeutic and diagnostic perspectives for this disabling disease without curative treatment.