Single cell genomics reveals activation signatures of endogenous SCAR's networks in aneuploid human embryos and clinically intractable malignant tumors
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- 作者：Gennadi V. Glinsky ; gglinskii@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human endogenous stem cell-associated retroviruses (SCARs) ; Human-specific regulatory sequences ; Human embryos ; LTR7/HERVH ; Therapy-resistant cancers ; Cancer stem cells
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：381
- 期：1
- 页码：176-193
- 全文大小：6136 K
文摘
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Single cell analysis of SCARs transcriptome in human preimplantation embryos (hPE).
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Activation of specific HERVH loci during the transition from oocytes to zygotes.
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HERVH activation signals linked with aneuploidy in hPE and during tumor progression.
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Genome-wide analyses of SCAR's networks in 12,093 tumors across 29 cancer types.
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Pan-cancer SCAR signatures of somatic non-silent mutations (SNMs) in lethal tumors.